Complex neuronal connectivity patterns develop through the action of guidance cues and their neuronal receptors. Multiple cues, including semaphorin proteins, provide repulsive and attractive influences that sculpt developing neuronal trajectories. Studies in invertebrates and vertebrates reveal the receptors and intracellular signaling mechanisms semaphorins use to guide neurons and regulate their morphology. This work shows how semaphorins function in neuronal and non-neuronal cell types and suggests strategies for promoting neuronal regeneration.

08/08/07